"Dietary supplement for joint pain*. PAENWIN constituents work in harmony with nature and helps to reduce joint pain, stiffness and muscles sprains*. Alleviates discomfort associated with backaches, frozen shoulders, overexertion and arthritis*.
PAENWIN is a phytopharmaceutical formulation that relieves joint and bone aches associated with various orthopedic ailments.
The anti-inflammatory properties of Curcuma longa, Withania Somnifera and Pluchea lanceolata alleviates pain reduces degeneration of glycosaminoglycans (GAGs), inhibits master cytokines and prevents cartilage damage.
Research and Clinical studies show –Haldi (Curcuma longa) has long history of use in Ayurvedic medicine as a treatment for inflammatory conditions.
Haldi constituents include the three curcuminoids: curcumin (diferuloylmethane; the primary constituent and the one responsible for its vibrant yellow color), demethoxycurcumin, and bisdemethoxycurcumin, as well as volatile oils (tumerone, atlantone, and zingiberone), sugars, proteins, and resins.
Curcumin was able to produce an anti-inflammatory effect by inhibiting the pro-inflammatory mediators, i.e. PGE2, NO, IL-6 and IL-8.
Shallaki gum resin (Boswellia serrate) contains oils, terpenoids, sugars, and volatile oils. Up to 16 percent of the resin is essential oil, the majority being alpha-thujene and p-cymene.
Four pentacyclic triterpene acids are also present, with beta-boswellic acid being the major constituent are responsible for inhibition of pro-inflammatory enzymes. Out of these four boswellic acids, acetyl-11-keto-ß-boswellic acid is the most potent inhibitor of 5-lipoxygenase, an enzyme responsible for inflammation.
Ashwgandha (Withania somnifera) root major biochemical constituents are steroidal alkaloids and steroidal lactones in a class of constituents called withanolides. Studies show protective effect in arthritis. Short-term chondroprotective activity in 50% of Osteoarthritis (OA) cases tested in an explant model of human OA cartilage damage